Silodosin

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
KMD-3213, KAD 3213, Urief, Rapaflo, Silodyx
API & Intermediates
KAPI3F01
160970-54-7
MFCD00930170
5312125
8175841
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Silodosin
C25H32F3N3O4
495.54
≥98%(HPLC)
White to Yellow Solid
105-108°C
100mg,500mg,1g,5g,10g,20g,50g,100g,500g and 1kg
-20°C Freezer
Silodosin (KMD-3213, KAD 3213, Urief, Rapaflo, Silodyx) is an alfa1A-adrenoceptor antagonist with high uroselectivity for treatment of benigh prostatic hypertrophy. Silodosin causes practically no orthostatic hypotension (in contrast to other alfa1A blockers). Since Silodosin is a highly selective inhibitor of the alfa1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other alfa1A blockers).
KMD-3213, a novel α1A-adrenoceptor antagonist, potently inhibits the functional α1-adrenoceptor in human prostate. [1]
KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat model. [2]
Pharmacophore identification of α1A-adrenoceptor antagonists. [3]
Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. [4]
Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia. [5]
Silodosin is effective for treatment of LUTS in men with BPH: a systematic review. [6]
References:
[1] N.Moriyamaa, et al, Eur. J. Pharmacol., 1997, 331(1), pp 39-42.
[2] K.Akiyama, et al, J. Pharmacol. Exp. Ther., 1999, 291(1), pp 81-91.
[3] M.Y.Li, et al, Bioorg. Med. Chem. Lett., 2005, 15(3), pp 657-664.
[4] K. Kawabe, et al, BJU Int., 2006, 98(5), pp 1019-1024.
[5] M.Yoshida, et al, Clin. Interv. Aging, 2011, 6, pp 161-172.
[6] H.Ding, et al, Asian J. Androl., 2013, 15(1), pp 121-128.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P264,P280,P305+P351+P338

NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on Ph. Eur. Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by EDQM can be found here.
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