Sitagliptin phosphate monohydrate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
MK-0431
API & Intermediates
KAPI6F01
654671-77-9
MFCD10001393
11591741
14530587
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Sitagliptin phosphate monohydrate
C₁₆H₁₅F₆N₅O•H₃PO₄•H₂O
523.33
≥98%(HPLC)
White Solid
216-219°C
100mg,500mg,1g,5g,10g,20g,50g,100g,500g and 1kg
-20°C Freezer
Sitagliptin phosphate monohydrate (originally known as MK-0431) is a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of type 2 diabetes. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release, stimulates insulin release and lowers blood glucose.
Sitagliptin: a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. [1]
Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes. [2]
Sitagliptin. [3]
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. [4]
References:
[1] S.Miller, et al, Ann. Pharmacother., 2006, 40(7-8), pp 1336-1343.
[2] B.Gallwitz, Drugs Today(Barc.), 2007, 43(1), pp 13-25.
[3] K.A.Lyseng-williamson, Drugs, 2007, 67(4), pp 587-597.
[4] V.A.Gault, et al, Diabetes Obes. Metab., 2015, 17(4), pp 403-413.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P264,P280,P305+P351+P338
29335995900
NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on Ph. Eur. Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by EDQM can be found here.
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