(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Sofosbuvir Intermediate 5, Sofosbuvir side chain N-1
API & Intermediates
KUMI5F10
1334513-02-8

75288590
20891726
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
C18H17F5NO5P
453.30
≥98%(HPLC)
White Solid
130-134°C
500mg,1g,5g,10g,25g,50g and 100g
-20°C Freezer
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester (also known as Sofosbuvir Intermediate 5) is a pharmaceutical intermediate for the synthesis of the Sofosbuvir used for the treatment of hepatitis C.
Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro. [1]
Synthesis and biological evaluation of a novel β-D-2'-deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection. [2]
References:
[1] E.M.Tyndall, et al, Bioorg. Med. Chem. Lett., 2015, 25(4), pp 869-873.
[2] E.Li, et al, Eur. J. Med. Chem., 2018, 143, PP 107-113.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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