N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Sofosbuvir, PSI-7977, GS-7977
API & Intermediates
KAPI1F01
1190307-88-0
MFCD18782704
45375806
20867484
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester
C22H29FN3O9P
529.46
≥98%
White Solid
122-126°C
10g,20g,50g,100g,500g,1kg and 5kg
-20°C Freezer
Sofosbuvir (formally labeled as PSI-797, GS-7977) is a phosphoramidate prodrug and nucleotide polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. It, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM), effective in vitro and in vivo. Multiple clinical trials demonstrated that treatments including sofosbuvir have higher sustained virologic response rates for genotypes 1, 2, 3, 4 and 6 in comparison with treatments that include only peginterferon and ribavirin. In addition, the side-effect profile of sofosbuvir and ribavirin dual treatment has an improved tolerability in comparison with treatment regimes that include interferon-based options.
Sofosbuvir, a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infection. [1]
Reference:
[1] D.A.Herbst, et al, Expert Opin. Investig. Drugs, 2013, 22(4), pp 527-536.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H373
P260,P314

NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on USP Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by USP can be found here.
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