TAK-438

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Vonoprazan Fumarate
API & Intermediates
KAPI1F16
1260141-27-2
MFCD18633280
45375887

Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
TAK-438
C21H20FN3O6S
461.46
≥99%(HPLC)
White Solid
203-209°C
500mg,1g,2g,5g,10g,25g,50g,100g and 500g
-20°C Freezer
TAK-438 (also known as Vonoprazan Fumarate) is a first-in-class potassium-competitive acid blocker (P-CAB) which competitively blocks the potassium-binding site of H+, K+-adenosine triphosphate (ATP)ase. It is used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. [1]
Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438). [2]
A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. [3]
The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations. [4]
Vonoprazan fumarate for the management of acid-related diseases. [5]
Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. [6]
References:
[1] Y.Hori, et al, J. Pharmacol. Exp. Ther., 2010, 335(1), pp 231-238.
[2] J.M.Shin, et al, J. pharmacol. Exp. Ther., 2011, 339(2), pp 412-420.
[3] Y.Hori, et al, J. Pharmacol. Exp. Ther., 2011, 337(3), pp 797-804.
[4] H.Echizen, et al, Clin. Pharmacokinet., 2016, 55(4), pp 409-418.
[5] I.Martinucci, et al, Expert. Opin. Pharmacother., 2017, 18(11), pp 1145-1152.
[6] K,Sugano, Therap. Adv. Gastroenterol., 2018, 11:1756283X17745776.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



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