Tedizolid phosphate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
TR-701 FA
API & Intermediates
KAPI1F09
856867-55-5
MFCD28098176
11476460

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tedizolid phosphate
C17H16FN6O6P
450.32
≥99.8%(HPLC)
White Solid
>235°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Tedizolid phosphate (also known as TR-701 FA) is the prodrug form of the microbiologically active molecule Tedizolid(TR-700), a novel orally and intravenously administered oxazolidinone antibacterial agent. Tedizolid phosphate is rapidly converted by non-specific phosphatases to tedizolid, which inhibits the growth of S. aureus, S. epidermidis, E. faecalis, E. faecium, S. pneumoniae, and S. pyogenes (MICs = 0.25-1 μg/ml). In vivo, tedizolid phosphate (15 mg/kg) reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by methicillin-resistant S. aureus (MRSA). It also reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection and increases survival in a rabbit model of MRSA necrotizing pneumonia.
In Vitro Activity of TR-700, the Active Ingredient of the Antibacterial Prodrug TR-701, a Novel Oxazolidinone Antibacterial Agent. [1]
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines. [2]
Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate. [3]
Comparative Efficacies of Tedizolid Phosphate, Vancomycin, and Daptomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis. [4]
Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus. [5]
Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia. [6]
References:
[1] R.Schaadt, et al, Antimicrob. Agents Chemother., 2009, 53(8), pp 3236-3239.
[2] S.Lemaire, et al, J. Antimicrob. Chemohter., 2009, 64(5), pp 1035-1043.
[3] V.Ong, et al, Drug Metab. Dispos., 2015, 42(8), pp 1275-1284.
[4] L.C.Chan, et al, Antimicrob. Agents Chemother., 2015, 59(6), pp 3252-3256.
[5] A.S.Bayer, et al, Antimicrob. Agents Chemother., 2016, 60(8), pp 5092-5096.
[6] V.T.Le, et al, Antimicrob. Agents Chemother., 2017, 61(4), pp e02734-02716.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods



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