Tert-butyl 4-bromo-2-fluorobenzoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-bromo-2-fluoro-benzoic acid tert-butyl ester, Venetoclax intermediate
API & Intermediates
KUMI1F80
889858-12-2
MFCD08703426
46738774
14580596
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Tert-butyl 4-bromo-2-fluorobenzoate
C11H12BrFO2
275.12
≥99%
Colorless to yellowish oily Liquid
279-280°C
5g,10g,25g,50g,100g and 500g
Store at 2-8°C
Tert-butyl 4-bromo-2-fluorobenzoate is a pharmaceutical intermediate for the synthesis of Venetoclax used to treat chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.
Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine. [1]
Preparation of t‐Butyl‐3‐Bromo‐5‐Formylbenzoate Through Selective Metal‐Halogen Exchange Reactions. [2]
References:
[1] M.D. Wendt, et al, Tetrahedron Lett., 2010, 51(4), pp 641-644.
[2] J.D. Arredondo, et al, Org. Synth., 2012, 89, pp 460-470.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods


29163990
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