Tert-butyl 4-bromo-2-fluorobenzoate is a pharmaceutical intermediate for the synthesis of Venetoclax used to treat chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.
Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine.[1]
Preparation of t‐Butyl‐3‐Bromo‐5‐Formylbenzoate Through Selective Metal‐Halogen Exchange Reactions.[2]