Tert-butyl 4-bromo-2-fluorobenzoate

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

4-bromo-2-fluoro-benzoic acid tert-butyl ester, Venetoclax intermediate

API & Intermediates

KUMI1F80

889858-12-2

MFCD08703426

46738774

14580596

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Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Boiling Point

Packaging

Storage

Tert-butyl 4-bromo-2-fluorobenzoate

C₁₁H₁₂BrFO₂

275.12

≥99%

Colorless to yellowish oily Liquid

279-280°C

5g,10g,25g,50g,100g and 500g

Store at 2-8°C

Tert-butyl 4-bromo-2-fluorobenzoate is a pharmaceutical intermediate for the synthesis of Venetoclax used to treat chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.

Ortho selectivity in S_NAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine. [1]

Preparation of t‐Butyl‐3‐Bromo‐5‐Formylbenzoate Through Selective Metal‐Halogen Exchange Reactions. [2]

References:

[1] M.D. Wendt, et al, Tetrahedron Lett., 2010, 51(4), pp 641-644.

[2] J.D. Arredondo, et al, Org. Synth., 2012, 89, pp 460-470.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Not classified as a dangerous goods

29163990

NONH for all modes of transport

1. Product Specification

Product Specification_Tert-butyl 4-bromo-2-fluorobenzoate

2. Safety Data Sheet

Available on request.

Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.

Tert-butyl 4-bromo-2-fluorobenzoate

4-bromo-2-fluoro-benzoic acid tert-butyl ester, Venetoclax intermediate

API & Intermediates

KUMI1F80

889858-12-2

MFCD08703426

46738774

14580596

Tert-butyl 4-bromo-2-fluorobenzoate

Tert-butyl 4-bromo-2-fluorobenzoate is a pharmaceutical intermediate for the synthesis of Venetoclax used to treat chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.

Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine. [1]

Preparation of t‐Butyl‐3‐Bromo‐5‐Formylbenzoate Through Selective Metal‐Halogen Exchange Reactions. [2]

Ortho selectivity in S_NAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine. [1]