Tianeptine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Tianeptine Acid, Tianeptine [INN], Tianeptinum
API & Intermediates
KAPI0F43
66981-73-5
 
68870

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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tianeptine
C21H25ClN2O4S
436.95
≥98% (HPLC)
White to Off-white Solid
129-131°C
5g,10g,25g,50g,100g,250g and 500g
Store at 2-8°C temp.
Tianeptine is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. In terms of chemical structure, it is technically a tricyclic antidepressant (TCA), but it has a very different drug profile than other TCAs, and is not usually grouped with them.
Tianeptine, a selective enhancer of serotonin uptake in rat brain. [1]
Antidepressant and anxiolytic activities of tianeptine: an overview of clinical trials. [2]
Neuroprotective properties of tianeptine: interactions with cytokines. [3]
Neurobiological and clinical effects of the antidepressant tianeptine. [4]
The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. [5]
References:
[1] T.Mennini, et al, Naunyn-Schmiedebergs Arch. Pharmacol., 1987, 336(5), pp 478-482.
[2] R.Defrance, et al, Clin. Neuropharmacol., 1988, 11(Suppl. 2), pp S74-S82.
[3] F.Plaisant, et al, Neurophamacology, 2003, 44(6), pp 801-809.
[4] S.Kasper, et al, CNS Drugs, 2008, 22(1), pp 15-26.
[5] M.M.Gassaway, et al, Transl. Psychiatry, 2014, 4, e411.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Not a dangerous goods



NONH for all modes of transport


1. Product Specification
2. Safety Data Sheet
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