Ticagrelor

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
AR-C 126532XX, AZD 6140
API & Intermediates
KAPI2F02
274693-27-5
MFCD09954148
9871419
15468079
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ticagrelor
C23H28F2N6O4S
522.57
≥98%(HPLC)
White Solid
180-182°C
100mg,500mg,1g,5g,10g,20g,50g,100g,500g and 1kg
-20°C Freezer
Ticagrelor (also known as AR-C 126532XX, AZD 6140) is the first reversible antagonist of the platelet purinergic P2Y12 receptor, which can provide faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. It is commonly used to reduce cardiovascular death and heart attacks in patients with acute coronary syndrome (ACS).
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. [1]
P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. [2]
Advances in antiplatelet therapy. [3]
Identification of High-Affinity P2Y12 Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone. [4]
Advances in antiplatelet technologies to improve cardiovascular disease morbidity and mortality: a review of ticagrelor. [5]
References:
[1] J.P.Bassand, et al, Eur. Heart J., 2007, 28(13), pp 1598-1660.
[2] L.Wallentin, Eur. Heart J., 2009, 30(16), pp 1964-1977.
[3] A.D.Michelson, Hematology. Am. Soc. Hematol. Educ. Program, 2011, 2011, pp 62-69.
[4] G.Zech, et al, J. Med. Chem., 2012, 55(20), pp 8615-8629.
[5] E.M.Davis, et al, Clin. Pharmacol., 2013, 5, pp 67-83.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H319,H411
P264,P280,P273,P305+P351+P338

NONH for all modes of transport
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