Velpatasvir

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GS5816
API & Intermediates
KAPI0F30
1377049-84-7

67683363
23709173
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Velpatasvir
C49H54N8O8
883.02
≥99%
Light yellow to Brown Solid

500mg,1g,5g,10g,25g,50g and 100g
-20°C Freezer
Velpatasvir (also known as GS5816) is a hepatitis C virus (HCV) nonstructural (NS) protein NS5A inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.
1191 GS-5816, a second generation HCV NS5A inhibitor with potent antiviral activity broad genotypic coverage and a high resistance barrier. [1]
Hepatitis C virus NS5A inhibitors and drug resistance mutations. [2]
A phase 1, randomized, dose-ranging study of GS-5816, a once-daily NS5A inhibitor, in patients with genotype 1-4 hepatitis C virus. [3]
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial. [4]
Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection. [5]
References:
[1] G.Cheng, et al, J. Hepatol., 2013, 58(S1), pp S484-S485.
[2] S.nakamoto, et al, World J. Gastronenterol., 2014, 20(11), pp 2902-2912.
[3] E.Lawitz, et al, J. Viral Hepat., 2015, 22(12), pp 1011-1019.
[4] E.J.Gane, et al, Gastroenterology, 2016, 151(5), pp 902-909.
[5] M.Bourliere, et al, N. Engl. J. Med., 2017, 376(22), pp 2134-2146.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



NONH for all modes of transport
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