1-(2-Fluoro-6-(trifluoromethyl)benzyl)urea

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-[2-Fluoro-6-(trifluoromethyl)benzyl]urea, Elagolix intermediate 3
API & Intermediates
KUMI4F70
830346-46-8
MFCD12546644
22037856
14346133
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(2-Fluoro-6-(trifluoromethyl)benzyl)urea
C9H8F4N2O
236.17
≥98%
White to Off-white Solid

5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
1-(2-Fluoro-6-(trifluoromethyl)benzyl)urea (aka Elagolix intermediate 3) is a pharmaceutical intermediate typically used in the preparation of Elagolix, as  gonadotropin-releasing hormone antagonist (GnRH antagonist), in treatment of pain associated with endometriosis in women.
Discovery of sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6- [trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin -1-yl] -1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. [1]
Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain. [2]
References:
[1] C.Chen, et al, J. Med. Chem., 2008, 51(23), pp 7478-7485.
[2] M.Ezzati, et al, Womens Health(Lond), 2015, 11(1), pp 19-28.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P264,P302+P352,P304+P340,P305+P351+P338
29211999
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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