1-(2-Pyrimidyl)piperazine is a piperazine-based building block typically used as derivatization reagent for the carboxyl groups on peptides and phosphopeptides. It is also used in the preparation of some pharmaceutically active compounds.
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. 
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. 
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides. 
Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry. 
 L.Munoz, et al, J. Neuroinflammation, 2007, 4:21(pp 1-14).