1-(2-Pyrimidyl)piperazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-(2-pyridinyl)piperazine, 2-(1-Piperazinyl)pyrimidine
API & Intermediates, Derivatization reagents
KUMI0F220
20980-22-7
MFCD00040742
88747
151178
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Boiling Point
Packaging
Storage
1-(2-Pyrimidyl)piperazine
C8H12N4
164.21
≥98%
White to Pale Yellow Solid (Crystal Lump)
32-34°C
277°C
5g,10g,20g,50g,100g,500g, and 1kg
Store at 2-8 temp.
1-(2-Pyrimidyl)piperazine is a piperazine-based building block typically used as derivatization reagent for the carboxyl groups on peptides and phosphopeptides. It is also used in the preparation of some pharmaceutically active compounds.
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. [1] 
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. [2] 
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides. [3] 
Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry. [4] 
References:
[1] L.Munoz, et al, J. Neuroinflammation, 2007, 4:21(pp 1-14).
[2] D.M. Sikazwe, et al, Bioorg. Med. Chem., 2009, 17(4), pp 1716-1723.
[3] L.Zhang, et al, Protemics, 2009, 9(16), pp 4093-4097.
[4] X.Qiao, et al, Rapid Commun. Mass Spectrom., 2011, 25(5), pp 639-646.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933599590
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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