1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Methylpyrazole-4-boronic acid pinacol ester
API & Intermediates
KUMI0F954
761446-44-0
MFCD03789259
2773987
9903888
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
C10H17BN2O2
208.07
≥98%
White to Brown Solid
67-69°C
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (also known as 1-Methylpyrazole-4-boronic acid pinacol ester) is commonly used as reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer, and positive allosteric modulators (PAMs) of the M1 receptor, SRC kinase inhibitors and selective CYP11B1 inhibitors.
An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester and its corresponding lithium hydroxy ate complex: application in Suzuki couplings. [1]
The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors. [2]
Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders. [3]
References:
[1] P.R.Mullens, Tetrahedron Lett., 2009, 50(49), pp 6783-6786.
[2] M.Xin, et al, Bioorg. Med. Chem. Lett., 2013, 23(24), pp 6777-6783.
[3] L.B.Teal, et al, Adv. Pharmacol., 2019, 86, pp 153-196.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2934999090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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