(1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-amine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
API & Intermediates
KUMI2F255
1006614-49-8
MFCD16621157
52914940
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-amine hydrochloride
C7H7Cl2N3O2S
268.11
≥98%
White to Off-White Solid

5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-amine hydrochloride is a pharmaceutical intermediate that typically used in the preparation of Ticagrelor, as an antagonist of the P2Y12 receptor for the prevention of thrombotic events (for example stroke or heart attack) in different categories of patient.
P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use. [1]
Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone. [2]
Design, synthesis, and biological evaluation of new thiazolo[5,4-: D] pyrimidine derivatives as potent antiproliferative agents. [3]
References:
[1] L.Wallentin, Eur. Heart J., 2009, 30(16), pp 1964-1977.
[2] G.Zech, et al, J. Med. Chem., 2012, 55(20), pp 8615-8629.
[3] Z.H.Li. et al, MedChemComm., 2017, 8(8), pp 1655-1658.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P264,P280,P302+P352,P304+P340,P305+P351+P338
2933599090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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