2,2,2-Trifluoroethylamine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
 2-Amino-1,1,1-trifluoroethane hydrochloride
API & Intermediates
KUMI3F278
373-88-6
MFCD00012875
5311180
9772
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,2,2-Trifluoroethylamine hydrochloride
C2H5ClF3N
135.51
≥99%
White to Light Yellow Solid
220-222°C
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 2,2,2-Trifluoroethylamine hydrochloride is typically used in the derivatization of aqueous carboxylic acids to the corresponding 2,2,2-trifluoroethylamide derivative. It is also empolyed as intermediate in the preparation of pharamceutically active substances, e.g. JAK-1 Inhibitor, endogenous ligand for the CB cannabinoid receptors.
Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. [1]
Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection. [2]
A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy. [3]
References:
[1] S.Lin, et al, J. Med. Chem., 1998, 41(27), pp 5353-5361.
[2] Q.Ford, et al, J.Chromatogr. A., 2007, 1145(1-2), pp 241-245.
[3] J.M.Kremer, et al, Arthritis Rheumatol., 2016, 68(12), pp 2867-2877.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332
P280
2921199990
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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