2-Hydroxy-5-nitrobenzoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Nitrosalicylic acid, Anilotic acid
API & Intermediates
KUMI0F315
96-97-9
MFCD00007338
7318
2213719
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Hydroxy-5-nitrobenzoic acid
C7H5NO5
183.12
≥98%
Slightly Pale Yellow to Pale Brown Solid
228-230°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
2-Hydroxy-5-nitrobenzoic acid (aka 5-Nitrosalicylic acid, Anilotic acid) is a pharmaceutical fragment that typically used in the preparation of Mesalazine (Mesalamine, 5-aminosalicylic acid, 5-ASA) in the treatment of inflammatory bowel disease, including ulcerative colitis and crohn's disease.
Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. [1]
Simple one-pot green method for large-scale production of mesalamine, an anti-inflammatory agent. [2]
References:
[1] S.Kang, et al, Free Radic. Biol. Med., 2017, 108, pp 715-724.
[2] C.Vijaya Lakshmi, et al, Green Process. Synth., 2019, 8(1), pp 320-323.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P302+P352,P304+P340,P305+P351+P338
2918290090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
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