3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one is a pharmaceutical intermediate that typically used in the preparation of Apixaban, as a direct factor Xa inhibitor, in the treatment of blood clots and stroke in pepole with atrial fibrillation.
Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. 
Design, synthesis, and structure–activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element. 
Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity. 
 C.Frost, et al, Br. J. Clin. Pharmacol., 2013, 75(2), pp 476-487.