3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone
API & Intermediates
KUMI0F316
881386-01-2
 
58618150
14528639
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
C11H10Cl2N2O3
289.11
≥98%
White to Yellow Solid
170-172°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one is a pharmaceutical intermediate that typically used in the preparation of Apixaban, as a direct factor Xa inhibitor, in the treatment of blood clots and stroke in pepole with atrial fibrillation.
Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. [1]
Design, synthesis, and structure–activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element. [2]
Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity. [3]
References:
[1] C.Frost, et al, Br. J. Clin. Pharmacol., 2013, 75(2), pp 476-487.
[2] Y.Wang, et al, Bioorg. Med. Chem., 2016, 24(21), pp 5646-5661.
[3] X.Sun, et al, Bioorg. Med. Chem., 2017, 25(10), pp 2800-2810.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P302+P352,P304+P340,P305+P351+P338
2933790090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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