3,6-Dichloropyrazine-2-carbonitrile is an intermediate typically in the synthesis of 6-Fluoro-3- hydroxypyrazine-2-carboxamide commercially named Favipiravir, which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza (potentially treat the novel coronavirus pneumonia), acting on viral genetic copying to prevent its reproduction.
A practical and step-economic route to Favipiravir. [1]
The complete synthesis of favipiravir from 2-aminopyrazine. [2]
References:
[1] F.Liu, et al, Chem. Pap., 2017, 71(3), pp 1-6.
[2] Q.Guo, et al, Chem. Pap., 2019, 73(5), pp 1043-1051.
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RIDADR
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H302,H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport
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