4-(2-Methylpropyloxy)phenylmethylamine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(4-Isobutoxyphenyl)methanamine, p-Isobutyloxybenzylamin
API & Intermediates
KUMI0F311
4734-09-2
MFCD05053646
12201325
2717998
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-(2-Methylpropyloxy)phenylmethylamine
C11H17NO
179.26
≥98%
White to Yellow Solid
129-133°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
4-(2-Methylpropyloxy)phenylmethylamine (aka (4-Isobutoxyphenyl)methanamine, p-Isobutyloxybenzylamin) is a pharmaceutical intermediate typically used in the preparation of Pimavanserin, as a selective serotonin 2A receptor (5-HT2AR) inverse agonist, in treatment of psychotic symptoms in patients with Parkinson's disease.
On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis. [1]
(11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand. [2]
Novel and environmentally friendly synthesis of pimavanserin (5-HT2A receptor). [3]
References:
[1] U.Hacksell, et al, Neurochem. Res., 2014, 39(10), pp  2008-2017.
[2] V.L.Andersen, et al, Bioorg. Med. Chem. Lett., 2015, 25(5), pp 1053-1056.
[3] R.K.Papolu, et al, Asian J. Chem., 2019, 31(3), pp 723-726.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338
2921490090
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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