4-(4-Aminophenyl)morpholin-3-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-(3-Oxomorpholino)aniline
API & Intermediates
KUMI0F313
438056-69-0
MFCD08236742
11194854
9482023
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-(4-Aminophenyl)morpholin-3-one
C10H12N2O2
192.22
≥98%
White to Light Yellow Solid
174-177°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
4-(4-Aminophenyl)morpholin-3-one (aka 4-(3-Oxomorpholino)aniline) is a pharmaceutical intermediate typically used in the preparation of Rivaroxaban, as an anticoagulant medication (blood thinner), in treatment of blood clots, specifically deep vein thrombosis and pulmonary emboli.
Practical and efficient processes for the preparation of 4-(4-aminophenyl)morpholin-3-ones on a larger scale: Precursor of factor Xa inhibitors. [1]
Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. [2]
Rivaroxaban as an oral anticoagulant for stroke prevention in atrial fibrillation. [3]
References:
[1] W.W.K.R. Mederski, et al, Heterocycles, 2007, 74(C), pp 437-445.
[2] A.G.Turpie, Arterioscler Thromb. Vasc. Biol., 2007, 27(6), pp 1238-1247.
[3] A.G.Turpie, Ther. Clin. Risk Manag., 2014, 10, pp 197-205.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2934994400
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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