4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,6-Dichloro-5-nitro-2-propylsulfanylpyrimidine
API & Intermediates
KUMI0F314
145783-14-8
MFCD10698669
22268924
11523998
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
C7H7Cl2N3O2S
268.11
≥98%
Light Yellow to Yellow Liquid

5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine (aka 4,6-Dichloro-5-nitro-2-propylsulfanylpyrimidine) is a pharmaceutical intermediate that typically used in the preparation of Ticagrelor, as an antagonist of the P2Y12 receptor for the prevention of thrombotic events (for example stroke or heart attack) in different categories of patient.
P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use. [1]
Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone. [2]
Design, synthesis, and biological evaluation of new thiazolo[5,4-: D] pyrimidine derivatives as potent antiproliferative agents. [3]
References:
[1] L.Wallentin, Eur. Heart J., 2009, 30(16), pp 1964-1977.
[2] G.Zech, et al, J. Med. Chem., 2012, 55(20), pp 8615-8629.
[3] Z.H.Li. et al, MedChemComm., 2017, 8(8), pp 1655-1658.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P264,P280,,P302+P352,P304+P340,P305+P351+P338
2933599090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.