4-Chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
API & Intermediates
KUMI0F318
479633-63-1
MFCD09907939
44228967
14574302
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine
C13H10ClN3O2S
307.75
≥98%
White to Off-White Solid
140-148°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
4-Chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine (aka 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine) is a pharmaceutical intermediate that typically used in the preparation of various Janus Kinase (JAK) Inhibitors, such as Baricitinib,Tofacitinib, Oclacitinib and PF-06651600.
An Efficient Method for Synthesis of Tofacitinib Citrate. [1]
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. [2]
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. [3]
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor. [4]
References:
[1] S.Zhi, et al, J. Heterocyclic Chem., 2016, 53(4), pp 1259-1263.
[2] A.Thorarensen, et al, J. Med. Chem., 2017, 60(5), pp 1971-1993.
[3] M.L.Vazquez, et al, J. Med. Chem., 2018, 61(3), pp 1130-1152.
[4] H.Xu, et al, ACS Chem. Biol., 2019, 14(6), pp 1235-1242.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302

2935909099
NONH for all modes of transport

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2. Safety Data Sheet
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