4-Hydroxy-3-methoxy-5-nitrobenzaldehyde

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Nitrovanillin, Isonitrovanillin
API & Intermediates
KUMI0F321
6635-20-7
MFCD00007118
81134
1973746
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Hydroxy-3-methoxy-5-nitrobenzaldehyde
C8H7NO5
197.14
≥98%
Yellow to Deep Yellow Solid
172-175°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
4-Hydroxy-3-methoxy-5-nitrobenzaldehyde (aka 5-Nitrovanillin, Isonitrovanillin) is a pharmaceutical intermediate that typically used in the preparation of Entacapone as a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) for the treatment of Parkinson's disease.
Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. [1]
Entacapone increases and prolongs the central effects of L-DOPA in the 6-hydroxydopamine-lesioned rat. [2]
Synthesis and antitumor activity of feruloyl and caffeoyl derivatives. [3]
Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease. [4]
References:
[1] E.Nissinen, et al, Naunyn Schmiedebergs Arch. Pharmacol., 1992, 346(3), pp 262-266.
[2] M.Gerlach, et al, Naunyn Schmiedebergs Arch. Pharmacol., 2004, 370(5), pp 388-394.
[3] H.Chen, et al, Bioorg. Med. Chem. Lett., 2014, 24(18), pp 4367-4371.
[4] L.S.Li, et al, World J. Gastroenterol., 2015, 21(12), pp 3509-3518.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P305+P351+P338
2913000000
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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