5-Amino-4,6-dichloro-2-(propylthio)pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,6-Dichloro-2-propylsulfanylpyrimidin-5-amine
API & Intermediates
KUMI0F176
145783-15-9
MFCD16875503
11436336
11291328
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
C7H9Cl2N3S
238.14
≥98%
Yellow to Red Brown Solid

5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
5-Amino-4,6-dichloro-2-(propylthio)pyrimidine is an important intermediate typically used in the preparation of Ticagrelor, which is orally active reversible P2Y12 receptor antagonists for the prevention of thrombotic events (for example stroke or heart attack) in people with acute coronary syndrome or myocardial infarction with ST elevation.
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. [1]
Design, synthesis and preliminary antiproliferative activity studies of new diheteroaryl thioether derivatives. [2]
References:
[1] B.Springthorpe, et al, Bioorg. Med. Chem. Lett., 2007, 17(21), pp 6013-6018.
[2] Z.H.Li, et al, Bioorg. Med. Chem. Lett., 2017, 27(18), pp 4377-4382.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not listed as a hazardous substance or mixture
 
 
2933599590
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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