5-Bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Elagolix intermediate
API & Intermediates
KUMI4F72
830346-48-0
MFCD12546646
11682386
14346232
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
C13H9BrF4N2O2
381.12
≥98%
Light Yellow to Yellow Solid

5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
5-Bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione is a pharmaceutical intermediate typically used in the preparation of Elagolix, as a gonadotropin-releasing hormone antagonist (GnRH antagonist), in treatment of pain associated with endometriosis in women.
Discovery of sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6- [trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin -1-yl] -1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. [1]
Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain. [2]
Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist. [3]
Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists. [4]
References:
[1] C.Chen, et al, J. Med. Chem., 2008, 51(23), pp 7478-7485.
[2] M.Ezzati, et al, Womens Health(Lond), 2015, 11(1), pp 19-28.
[3] S.M.Kim, et al, J. Med. Chem., 2016, 59(19), pp 9150-9172.
[4] S.M.Kim, et al, Eur. J. Med Chem., 2018, 145, pp 413-424.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P260,P280,,P302+P352,P304+P340,P305+P351+P338
29339980
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
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