5-Bromo-1H-pyrrolo[2,3-b]pyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Bromo-7-azaindole
API & Intermediates
KUMI0F317
183208-35-7
MFCD06659677
10307932
8253948
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Bromo-1H-pyrrolo[2,3-b]pyridine
C7H5BrN2
197.03
≥98%
White to Yellow Solid
176-180°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
5-Bromo-1H-pyrrolo[2,3-b]pyridine (aka 5-Bromo-7-azaindole) is a pharmaceutical intermediate that typically used in the preparation of ABT-199, as a potent and selective BCL-2 inhibitor, in the treatment of chronic lymphocytic leukemia (CLL). Recently it is also employed in the preparation of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors.
ABT-199: A new hope for selective BCL-2 inhibition. [1]
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. [2]
Discovery of novel 7-azaindoles as PDK1 inhibitors. [3]
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity. [4]
References:
[1] M.S.Davids, et al, Cancer Cell, 2013, 23(2), pp 139-141.
[2] A.J.Soners, et al, Nat. Med., 2013, 19(2), pp 202-208.
[3] M.Wucherer-Plietker, et al, Bioorg. Med. Chem. Lett., 2016, 26(13), pp 3073-3080.
[4] C.Yang, et al, ACS Med. Chem. Lett., 2017, 8(8), pp 875-880.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H318
P280,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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