5-Bromo-2-oxo-1H-pyrazine-3-carboxamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-Bromo-3-hydroxypyrazine-2-carboxamide
API & Intermediates
KUMI0F940
259793-88-9
MFCD20528005
9794418
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Bromo-2-oxo-1H-pyrazine-3-carboxamide
C5H4BrN3O2
218.01
≥97%
White to Light Yellow Solid
 
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
 5-Bromo-2-oxo-1H-pyrazine-3-carboxamide (also known as 6-Bromo-3-hydroxypyrazine-2-carboxamide) is an pharmaceutical intermediate typically used in the preparation of Favipiravir (T-705), which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza (experimental treatment of the emergent COVID-19 in 2020), acting on viral genetic copying to prevent its reproduction.
Favipiravir (T-705), a novel viral RNA polymerase inhibitor. [1]
A practical and step-economic route to Favipiravir. [2]
The complete synthesis of favipiravir from 2-aminopyrazine. [3]
References:
[1] Y.Furuta, et al, Antiviral Res., 2013, 100(2), pp 446-454.
[2] F.Liu, et al, Chem. Pap., 2017, 71(3), pp 1-6.
[3] Q.Guo, et al, Chem. Pap., 2019, 73(5), pp 1043-1051.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport
 
1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
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