5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Chloranyl-3-nitro-pyrazolo[1,5-a]pyrimidine
API & Intermediates
KUMI0F398
1363380-51-1
MFCD22415211
72207283
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine
C6H3ClN4O2
198.57
≥97%
White to Brown Solid
 
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate typically used in the preparation of LOXO-101(ARRY-470), which is an inhibitor of tropomyosin kinase receptors(TrkA,TrkB,and TrkC) in treating the solid tumors with NTRK gene fusions.
An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. [1]
Reference:
[1] R.C.Doebele, et al, Cancer Discov., 2015, 5(10), pp 1049-1057.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P280,P305+P351+P338
29339980
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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