(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GS 441524, GS441524, GS-441524, Remdesivir-metabolite
API & Intermediates
KUMI0F935
1191237-69-0
 
44468216
22238455
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
GS 441524
C12H13N5O4
291.26
≥98%
White to Off-white Solid
 
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 GS 441524 is a small molecule nucleoside analog acting as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. It is furtherly used for the preparation of GS-5734, which is a novel antiviral investigational drug originally for the treatment of Ebola virus disease and Marburg virus infections and has subsequently also been found to show antiviral activity against coronaviruses(e.g. SARS-Cov-2/Covid-19).
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. [1]
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. [2]
The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. [3]
Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. [4]
Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. [5]
References:
[1] A.Cho, et al, Bioorg. Med. Chem. Lett., 2012, 22(8), pp 2705-2707.
[2] D.Siegel, et al, J. Med. Chem., 2017, 60(5), pp 1648-1661.
[3] B.G.Murphy, et al, Vet. Microbiol., 2018, 219, pp 226-233.
[4] N.C.Pedersen, et al, J. Feline Med. Surg., 2019, 21(4), pp 271-281.
[5] V.C.Yan, et al, ACS Med. Chem. Lett., 2020, 11(7), pp 1361-1366.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as hazardous substance or mixture


2934999001
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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