N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-(4-Fluorobenzylamino)-1-methylpiperidine, A6255
API & Intermediates
KUMI1F242
359878-47-0
MFCD00979813
2846645
14530704
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
C13H19FN2
222.30
≥98%
Light Yellow to Yellow Solid
139-140°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8 temp.
N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (aka 4-(4-Fluorobenzylamino)-1-methylpiperidine, A6255) is a pharmaceutical intermediate typically used in the preparation of Pimavanserin, as a selective serotonin 2A receptor (5-HT2AR) inverse agonist, in treatment of psychotic symptoms in patients with Parkinson's disease.
On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis. [1]
Novel and environmentally friendly synthesis of pimavanserin (5-HT2A receptor). [2]
References:
[1] U.Hacksell, et al, Neurochem. Res., 2014, 39(10), pp  2008-2017.
[2] R.K.Papolu, et al, Asian J. Chem., 2019, 31(3), pp 723-726.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H318,H335
P261,P280,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
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