(2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Boc-2-methyl-D-proline, (R)-N-Boc-2-methylproline
API & Intermediates
KUMI0F392
166170-15-6
MFCD06797554
41097301
15016484
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
C11H19NO4
229.28
≥98%(ee98%)
White to Light Yellow Solid
127-129°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
 (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (also named as N-Boc-2-methyl-D-proline, (R)-N-Boc-2-methylproline) is an intermediate typically used in the preparation of ABT-888, which is a PARP inhibitor for the treatment of anti-cancer.
Discovery of 2-alkyl-1-arylsulfonylprolinamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors. [1]
Synthesis of (R)-Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase Inhibitor. [2]
References:
[1] J.Yu, et al, ACS Med. Chem. Lett., 2012, 3(10), pp 793-798.
[2] L.Kolaczkowski, et al, J. Org. Chem., 2019, 84(8), pp 4837-4845.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not listed as a hazardous substance or mixture
 
 
2933998090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.