(S)-1-(Tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Boc-2-methyl-L-proline, (S)-N-Boc-2-methylproline
API & Intermediates
KUMI0F391
103336-06-7
MFCD08706361
11206950
6403143
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(S)-1-(Tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid
C11H19NO4
229.28
≥98%(ee98%)
White to Light Yellow Solid
129-132°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
 (S)-1-(Tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (also named as N-Boc-2-methyl-L-proline, (S)-N-Boc-2-methylproline) is an important intermediate typically used in the preparation of ACT-541468, which is a dual orexin receptor antagonist (DORA) in the treatment of insomnia.
Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS?. [1]
Understanding sleep-wake mechanisms and drug discovery. [2]
The use of physiology-based pharmacokinetic and pharmacodynamic modeling in the discovery of the dual orexin receptor antagonist ACT-541468. [3]
References:
[1] Y.Xu, et al, Free Radic. Res., 2007, 41(1), pp 1-7.
[2] A.C.Equihua-Benitez, et al, Expert Opin. Drug Discov., 2017, 12(7), pp 643-657.
[3] A.Treiber, et al, J. Pharmacol. Exp. Ther., 2017, 362(3), pp 489-503.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not listed as a hazardous substance or mixture
 
 
2933998090
NONH for all modes of transport

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