N-Propyl-sulfamide sodium salt

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Propylamino sulfonamide sodium salt, Sodium propylsulfamoylazanide
API & Intermediates
KUMI0F175
1642873-03-7
MFCD28964001
127255792

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-Propyl-sulfamide sodium salt
C3H9N2NaO2S
160.17
≥98%
White to Off-white Solid

5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 N-Propyl-sulfamide sodium salt is a pharmaceutical intermediate typically used for the preparation of Macitentan, which is an endothelin receptor antagonist (ERA) for the treatment of pulmonary arterial hypertension (PAH).
The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist. [1]
Improved and single-pot process for the synthesis of macitentan, an endothelin receptor antagonist, via lithium amide-mediated nucleophilic substitutions. [2]
References:
[1] M.H.Bolli, et al, J. Med. Chem., 2012, 55(17), pp 7849-7861.
[2] K.M.Jagtap, et al, Monatshefte fur Chemie, 2018, 149, pp 653-661.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H315,H319,H335
P280,P305+P351+P338
2929900090
UN 1325 4.1/PG II

1. Product Specification
2. Safety Data Sheet
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