N-propylsulfamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-(Sulfamoylamino)propane
API & Intermediates
KUMI0F965
147962-41-2
MFCD12755184
13949558
15815754
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-propylsulfamide
C3H10N2O2S
138.19
≥98%
Off-white to Reddish-brown Waxy Solid
158-159°C
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 N-propylsulfamide is a pharmaceutical intermediate typically used for the preparation of Macitentan, which is an endothelin receptor antagonist (ERA) for the treatment of pulmonary arterial hypertension (PAH).
The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist. [1]
Improved and single-pot process for the synthesis of macitentan, an endothelin receptor antagonist, via lithium amide-mediated nucleophilic substitutions. [2]
References:
[1] M.H.Bolli, et al, J. Med. Chem., 2012, 55(17), pp 7849-7861.
[2] K.M.Jagtap, et al, Monatshefte fur Chemie, 2018, 149, pp 653-661.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302
P305+P351+P338
2929900090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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