N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Remdesivir Impurity 4
API & Intermediates
KUMI0F938
1354823-36-1
 
121304098
29506489
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester
C21H27N2O7P
450.42
≥99%
White to Off-white Solid
 
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester (also known as Remdesivir Impurity 4) is a phosphoramidate sidechain typically used for the preparation of GS-5734, which is a novel antiviral investigational drug originally for the treatment of Ebola virus disease and Marburg virus infections and has subsequently also been found to show antiviral activity against coronaviruses (e.g. SARS-Cov-2/Covid-19).
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. [1]
Reference:
[1] D.Siegel, et al, J. Med. Chem., 2017, 60(5), pp 1648-1661.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as hazardous substance or mixture


2929900090
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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