Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
PSI-6206
API & Intermediates
KUMI1F212
863329-66-2
MFCD27918669
11311503
10267735
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2'-deoxy-2'-fluoro-2'-C-methyluridine
C10H13FN2O5
260.22
≥99%(HPLC)
White to Off-white Solid
236-239°C
5g,10g,25g,50g,100g,250g,500g and 1kg
-20°C Freezer
2'-deoxy-2'-fluoro-2'-C-methyluridine (Synonyms: PSI-6206) is a selective nucleoside polymerase inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. 
Pharmacokinetics of the Antiviral Agent β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine in Rhesus Monkeys. [1]
The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. [2]
Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus. [3]
Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates. [4]
Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides. [5]
References:
[1] G.Asif, et al, Antimicrob. Agents Chemother., 2007, 51(8), pp 2877-2882.
[2] E.Murakami, et al, Antimicrob. Agents Chemother., 2008, 52(2), pp 428-464.
[3] M.J.Sofia, et al, J. Med. Chem., 2010, 53(19), pp 7202-7218.
[4] B.S.Ross, et al, J. Org. Chem., 2011, 76(20), pp 8311-8319.
[5] U.Pradere, et al, Org. Lett., 2012, 14(17), pp 4426-4429.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods


2934999090
NONH for all modes of transport

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