3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid (also known as Ataluren, PTC124) is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins. It also empoyed as a potent inhibitor of firefly luciferase (FLuc).
PTC124 targets genetic disorders caused by nonsense mutations. 
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. 
Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124). 
Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis. 
A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays.
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