Capecitabine isa prodrug of antitumor antimetabolite, metabolized to the active form 5-fluorouracil (5-FU) by three enzymes located in the liver and in tumors.
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissue. [1]
Lapatinib plus capecitabine for HER2-positive advanced breast cancer. [2]
Capecitabine: an overview of the side effects and their management. [3]
References:
[1] M.Miwa, et al, Eur. J. Cancer, 1998, 34(8), pp 1274-1281.
[2] C.E.Geyer, et al, N. Engl. J. Med., 2006, 355(26), pp 2733-2743.
[3] M.W.Saif, et al, Anticancer Drugs, 2008, 19(5), pp 447-464.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Danger
H341,H335,H360
P201,P281,P308+P317
2934999090
NONH for all modes of transport
1. Product Specification
2. Safety Data Sheet
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