Diacerein (also known as diacetylrhein)is an inhibitor of Interleukin-1B (IL-1B) production commonly used for the treatment of joint diseases such as osteoarthritis (swelling and pain in the joints). An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain.
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocyte. 
Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption. 
 J.P.Pelletier, et al, J. Rheumatol., 1998, 25(12), pp 2417-2424.
 T.Tamura, et al, Eur. J. Pharmacol., 2002, 448(1), pp 81-87.
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