Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride. It is primarily used in the treatment of benign prostatic hyperplasia.
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1. [1]
Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. [2]
Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteridedesonide 0.05%: a clinical safety profile. [3]
Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer. [4]
Controlled release of dutasteride from biodegradable microspheres: in vitro and in vivo studies. [5]
References:
[1] G.Tian, et al, Biochemistry, 1994, 33(8), pp 2291-2296.
[2] H.N.Bramson, et al, J. Pharmacol. Exp. Ther., 1997, 282(3), pp 1496-1502.
[3] N.Makridakis, et al, J. Mol. Endocrinol., 2005, 34(3), pp 617-623.
[4] T.C.Shao, et al, J. Urol., 2007, 178(4 Pt 1), pp 1521-1527.
