Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Fluoroacetoacetic Acid Ethyl Ester
API & Intermediates, Fluorinated Building Blocks
KUMI1F214
1522-41-4
MFCD00215830
230078
1759115
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Ethyl 2-fluoroacetoacetate
C6H9FO3
148.13
≥97%(GC)
Colorless to Pale Yellow Liquid
183°C
5g,10g,20g,50g,100g,500g,1kg,5kg and 25kg
Store at 2-8 temp.
Ethyl 2-fluoroacetoacetate (Synonym: 2-Fluoroacetoacetic Acid Ethyl Ester) is a useful intermediate for the preparation of various fluorinated compounds. It is also used as alkylation/decarboxylation reagent in the synthesis of fluoroketones.
Alkylation and decarboxylation of ethyl 2-fluoro-3-oxobutanoate as a route to functionalised α-fluoro-ketones. [1]
Asymmetric Organocatalytic Direct Aldol Reactions of Ketones with α-Keto Acids and Their Application to the Synthesis of 2-Hydroxy-γ-butyrolactones. [2]
Fluorinated [1,2,4]triazolo[1,5-a]pyrimidines and [1,2,4]triazolo[5,1-c][1,2,4]triazines. [3]
References:
[1] J.Hutchinson, et al, Tetrahedron, 1998, 54(12), pp 2867-2876.
[2] X.Xu, et al, J. Org. Chem., 2007, 72(26), pp 9905-9913.
[3] E.Ulomskiy, et al, Chem. Heterocycl. Compd., 2011, 47(9), pp 1164-1169.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2918300090
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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