3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

FDI 6, NCGC00099374

API & Intermediates

KUMI4F29

313380-27-7

MFCD01416826

5175738

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png

Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

C₁₉H₁₁F₄N₃OS₂

437.43

≥98%(HPLC)

White to Beige Solid

50mg,100mg,200mg,500mg,1g,2g,5g and 10g

Store at 2-8°C

FDI 6 (also known as NCGC00099374) is a potent and specific inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) that blocks DNA binding. It displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription.

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. [1]

Is there potential to target FOXM1 for 'undruggable' lung cancers? [2]

[Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. [3]

Untying the knot of transcription factor druggability: Molecular modeling study of FOXM1 inhibitors. [4]

References:

[1] M.V. Gormally, et al, Nat. Commun., 2014, Nov. 12, 5:5165.

[2] V.V.Kalinichenko, et al, Expert. Opin. Ther. Targets, 2015, 19(7), pp 865-867.

[3] Y.Lin, et al, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017, 33(5), pp 611-616.

[4] S.A.Tabatabaei-Dakhili, et al, J. Mol. Graph. Model, 2018, 80, pp 192-210.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Not a hazardous substance or mixture

2934999090

NONH for all modes of transport

1. Product Specification

Product Specification_FDI 6

2. Safety Data Sheet

Available on request.

Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.

3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

FDI 6, NCGC00099374

API & Intermediates

KUMI4F29

313380-27-7

MFCD01416826

5175738

3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

FDI 6 (also known as NCGC00099374) is a potent and specific inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) that blocks DNA binding. It displaces ​FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription.

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. [1]

Is there potential to target FOXM1 for 'undruggable' lung cancers? [2]

[Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. [3]

Untying the knot of transcription factor druggability: Molecular modeling study of FOXM1 inhibitors. [4]

FDI 6 (also known as NCGC00099374) is a potent and specific inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) that blocks DNA binding. It displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription.