Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GW3965 HCl
API & Intermediates
KUMI3F160
405911-17-3
MFCD08276920
16078973
GW3965 hydrochloride is a synthetic liver X receptor (LXR) agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR).
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. [1]
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. [3]
LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. [4]
Action mechanisms of Liver X Receptors. [5]
References:
[1] J.L.Collins, et al, J. Med. Chem., 2002, 45(10), pp 1963-1966.
[2] S.B.Joseph, et al, Nat. Med., 2003, 9(2), pp 213-219.
[3] C.E.Leik, et al, Br. J. Pharmacol., 2007, 151(4), pp 450-456.
[4] A.Archer, et al, J. Lipid Res., 2013, 54(5), pp 1300-1311.
[5] C.Gabbi, et al, Biochem. Biophys. Res. Commun., 2014, 446(3), pp 647-650.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H318,H413
P280,P305+P351+P338
2922190090
NONH for all modes of transport
1. Product Specification
2. Safety Data Sheet
Available on request.
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