(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(S)​-​​α-​Methylproline hydrochloride, 2-Methyl-L-proline hydrochloride, MePro
API & Intermediates
KUMI0F84
1508261-86-6
MFCD04115802
72207643
28259658
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride
C6H12ClNO2
165.62
≥98%,ee99%
White to Light Yellow Solid
164-167°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride (also known as (S)​-​​α-​Methylproline hydrochloride, 2-Methyl-L-proline hydrochloride) is a useful chiral intermediate for the preparation of various pharmaceutically active substances, e.g. ABT-888, a PARP inhibitor for the treatment of anti-cancer, and ACT-541468, a Dual Orexin Receptor Antagonist for the treatment of Insomnia Disorder.
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468. [1]
Reference:
[1] A.Treiber, et al, J. Pharmacol. Exp. Ther., 2017, 362(3), pp 489-503.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P260,P280,P305+P351+P338+P337+P313
2933998090
NONH for all modes of transport


1. Product Specification
2. Safety Data Sheet
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