(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride (also known as (S)-α-Methylproline hydrochloride, 2-Methyl-L-proline hydrochloride) is a useful chiral intermediate for the preparation of various pharmaceutically active substances, e.g. ABT-888, a PARP inhibitor for the treatment of anti-cancer, and ACT-541468, a Dual Orexin Receptor Antagonist for the treatment of Insomnia Disorder.
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
 A.Treiber, et al, J. Pharmacol. Exp. Ther., 2017, 362(3), pp 489-503.
NONH for all modes of transport
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