Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Lu 28-179 hydrochloride
API & Intermediates
KUMI1F213
224177-60-0
MFCD28144522

14640899
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Siramesine hydrochloride
C30H32ClFN2O
491.05
≥98%(HPLC)
White to Off-white Solid
223-227°C
100mg,500mg,1g,2g and 5g
-20°C Freezer
Siramesine hydrochloride (Synonym: Lu 28-179 hydrochloride) is a potent and selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. 
The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. [1]
Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. [2]
Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. [3]
References:
[1] G.Skuza, et al, J. Pysiol. Pharmacol., 2006, 57(2), pp 217-229.
[2] J.Spirkoski, et al, Biochem. Pharmacol., 2012, 84(12), pp 1671-1680.
[3] M.H.Cesen, et al, Cell Death Dis., 2013, Oct 3;4:e818.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338,P302+P352
293490
NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.