(R)-3-((1-(1H-indol-3-yl)propan-2-yl)amino)-2,2-difluoropropan-1-ol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-Difluoro-3-[[(1R )-2-(1H -indol-3-yl)-1-methylethyl]amino]-1-Propanol
API & Intermediates
KUMI2F264
1953133-35-1
 
 
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(R)-3-((1-(1H-indol-3-yl)propan-2-yl)amino)-2,2-difluoropropan-1-ol
C14H18F2N2O
268.30
≥98%
White to Light Yellow Solid
 
5g,10g,20g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 (R)-3-((1-(1H-indol-3-yl)propan-2-yl)amino)-2,2-difluoropropan-1-ol is a pharmaceutical intermediate typically used as starting material in the preparation of GDC-9545 as an orally active and selective estrogen receptor (ER) antagonist for the treatment of cancer.
Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes. [1]
Reference:
[1] C.Metcalfe, et al, 2018 San Antonio Breast Cancer Symposium, December 4-8, San Antonio, Texas.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29349990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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