R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-((R)-2-Amino-1-propyl)-2-methoxybenzenesulphonamide
API & Intermediates
KUMI0F362
112101-81-2
MFCD07782137
10060387
8261293
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide
C10H16N2O3S
244.31
≥98%(ee99%)
White to Off-White Solid
166-170°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide is an important intermediate typically used for the preparation of α1-adrenoceptor antagonists, such as Tamsulosin (T006350) in the treatment of symptomatic benign prostatic hyperplasia (BPH), chronic prostatitis, and to help with the passage of kidney stones.
Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline α1-adrenoceptor antagonists. [1]
Efficacy and safety of tamsulosin in the treatment of urological diseases. [2]
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues. [3]
References:
[1] A.Leonardi, et al, J. Med. Chem., 1999, 42(3), pp 427-437.
[2] M.C.Michel, et al, Expert. Opin. Pharmacother., 2004, 5(1), pp 151-160.
[3] G.Sagratini, et al, Eur. J. Med. Chem., 2010, 45(12), pp 5800-5807.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not listed as a hazardous substance or mixture
 
 
2935009090
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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