(S)-5-Fluoro-3-methylisobenzofuran-1(3H)-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(3S)-5-Fluoro-3-methyl-phthalide
API & Intermediates
KUMI1F251
1803573-19-4
MFCD09878362
134970125
31761304
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(S)-5-Fluoro-3-methylisobenzofuran-1(3H)-one
C9H7FO2
166.15
≥98%
White to Light Yellow Solid
 
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
 (S)-5-Fluoro-3-methylisobenzofuran-1(3H)-one (also named as (3S)-5-Fluoro-3-methyl-phthalide) is a pharmaceutical intermediate typically used in the preparation of Lortalinib, which is an orally administered inhibitor of ALK and ROS1 for the treatment of ALK-positive metastatic non-small-cell lung cancer (NSCLC).
Developing an Asymmetric Transfer Hydrogenation Process for (S)-5-Fluoro-3-methylisobenzofuran-1(3H)-one, a Key Intermediate to Lorlatinib. [1]
Reference:
[1] S.Duan, et al, Org. Process Res. Dev., 2017, 21(9), pp 1340-1348.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not listed as a hazardous substance or mixture
 
 
 
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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