Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
DO3A-t-Bu-ester, DO3AtBu
API & Intermediates
KUMI0F329
122555-91-3
MFCD05865261
58516805
8454558
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate
C26H50N4O6
514.71
≥98%
White to Yellow Solid
180-182°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (also name as DO3A-t-Bu-ester, DO3AtBu) is a pharmaceutical intermedidate that typically used in the preparation of Gadobutrol as a gadolinium-based magnetic resonance imaging (MRI) contrast agent (GBCA).
A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications. [1]
Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-1,4,7-Trisacetic Acid (DO3A)-Ethoxybenzyl (EOB) Conjugate as a New Macrocyclic Hepatobiliary MRI Contrast Agent. [2]
Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent. [3]
References:
[1] S.Aime, et al, Chem. Commun., 1999, 16, pp 1577-1578.
[2] A.R.Baek, et al, J. Med. Chem., 2017, 60(12), pp 4861-4868.
[3] A.Babic, et al, Chemistry: A Eur. J., 2018, 24(16), pp 1348-1357.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
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2. Safety Data Sheet
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