3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
CL 218872
API & Intermediates
KAPI3F06
66548-69-4

107950
1221941
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine
C13H9F3N4
278.24
≥99%(HPLC)
White Solid
193~194°C
500mg,1g,5g,10g,25g,50g and 100g
-20°C Freezer
3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine (also known as CL 218872) is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors.
Benzodiazepine receptors: cellular and behavioral characteristics. [1]
Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. [2]
Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. [3]
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. [4]
References:
[1] A.S.Lippa, et al, Pharmacol. Biochem. Behav., 1979, 10(5), pp 831-843.
[2] R.F.Squires, et al, Pharmacol. Biochem. Behav., 1979, 10(5), pp 825-830.
[3] W.Sieghart, et al, Pharmacol. Rev., 1995, 47(2), pp 181-234.
[4] K.Yamaura, et al, Nat. Chem. Biol., 2016, 12(10), pp 822-830.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
Available on request.
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.